The Science Behind Ostenso

The Research Behind Ostenso Sleep Strips

Every claim on our site maps to a peer-reviewed study. Below are the nine that anchor the formulation.

Sublingual delivery

• Bartoli et al., 2025 — Sublingual melatonin pharmacokinetics. Drugs in R&D, Springer.
• 2025 PMC Review — Oral mucosal bioavailability synthesis. Pharmaceutics.

Melatonin

• Salehi et al., 2025 — Scoping review of 57 systematic reviews and 227 meta-analyses on melatonin and sleep. Phytotherapy Research. 80.9% of meta-analyses favored melatonin over placebo.
• Cruz-Sanabria et al., 2024 — Melatonin dose-response meta-analysis. Journal of Pineal Research.

Valerian root

• Shinjyo et al., 2020 — Systematic review + meta-analysis across 60 valerian sleep studies. Journal of Evidence-Based Integrative Medicine.

Chamomile

• Hieu et al., 2019 — Chamomile sleep meta-analysis, 12 RCTs. Phytotherapy Research.
• Dai et al., 2024 — Chamomile sleep review across 2,896 patients. Complementary Therapies in Medicine.

Lavender

• Kasper et al., 2019 — Lavender (Silexan) sleep mediation analysis. Phytomedicine.

Gummy dose accuracy

• Cohen et al., 2023 — 22 of 25 melatonin gummies (88%) inaccurately labeled. JAMA.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.